Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate

Background: Folylpoly-γ-glutamate synthetase (FPGS) converts intracellular folates and antifolates (for example, methotrexate (MTX)) to polyglutamates. Polyglutamylated folates and antifolates are retained in cells longer and are better substrates than their monoglutamate counterparts for enzymes in...

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Detalhes bibliográficos
Main Authors: Sohn, K-J, Smirnakis, F, Moskovitz, D N, Novakovic, P, Yates, Z, Lucock, M, Croxford, R, Kim, Y-I
Formato: Artigo
Idioma:Inglês
Publicado em: Copyright 2004 by Gut 2004
Assuntos:
Colon Cancer
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1774322/
https://ncbi.nlm.nih.gov/pubmed/15542523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2004.042713
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