Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate

Background: Folylpoly-γ-glutamate synthetase (FPGS) converts intracellular folates and antifolates (for example, methotrexate (MTX)) to polyglutamates. Polyglutamylated folates and antifolates are retained in cells longer and are better substrates than their monoglutamate counterparts for enzymes in...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Sohn, K-J, Smirnakis, F, Moskovitz, D N, Novakovic, P, Yates, Z, Lucock, M, Croxford, R, Kim, Y-I
Format: Artigo
Idioma:Inglês
Publicat: Copyright 2004 by Gut 2004
Matèries:
Colon Cancer
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1774322/
https://ncbi.nlm.nih.gov/pubmed/15542523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2004.042713
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars