Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate

Background: Folylpoly-γ-glutamate synthetase (FPGS) converts intracellular folates and antifolates (for example, methotrexate (MTX)) to polyglutamates. Polyglutamylated folates and antifolates are retained in cells longer and are better substrates than their monoglutamate counterparts for enzymes in...

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Main Authors: Sohn, K-J, Smirnakis, F, Moskovitz, D N, Novakovic, P, Yates, Z, Lucock, M, Croxford, R, Kim, Y-I
Format: Artigo
Sprog:Inglês
Udgivet: Copyright 2004 by Gut 2004
Fag:
Colon Cancer
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1774322/
https://ncbi.nlm.nih.gov/pubmed/15542523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2004.042713
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