Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate

Background: Folylpoly-γ-glutamate synthetase (FPGS) converts intracellular folates and antifolates (for example, methotrexate (MTX)) to polyglutamates. Polyglutamylated folates and antifolates are retained in cells longer and are better substrates than their monoglutamate counterparts for enzymes in...

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Autores principales: Sohn, K-J, Smirnakis, F, Moskovitz, D N, Novakovic, P, Yates, Z, Lucock, M, Croxford, R, Kim, Y-I
Formato: Artigo
Lenguaje:Inglês
Publicado: Copyright 2004 by Gut 2004
Materias:
Colon Cancer
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1774322/
https://ncbi.nlm.nih.gov/pubmed/15542523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2004.042713
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