γ-Glutamyl hydrolase modulation and folate influence chemosensitivity of cancer cells to 5-fluorouracil and methotrexate

BACKGROUND: γ-Glutamyl hydrolase (GGH) regulates intracellular folate and antifolates for optimal nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively. The modulation of GGH may therefore affect chemosensitivity of cancer cells, and exogenous folate levels may further modify thi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kim, S-E, Cole, P D, Cho, R C, Ly, A, Ishiguro, L, Sohn, K-J, Croxford, R, Kamen, B A, Kim, Y-I
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2013
Gaiak:
Translational Therapeutics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798974/
https://ncbi.nlm.nih.gov/pubmed/24045662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.579
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