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γ-Glutamyl Hydrolase: Kinetic Characterization of Isopeptide Hydrolysis Using Fluorogenic Substrates
γ-Glutamyl hydrolase, a cysteine peptidase, catalyzes the hydrolysis of poly-γ-glutamate derivatives of folate co-factors and many antifolate drugs. We have used internally quenched fluorogenic derivatives of glutamyl-γ-glutamate and (4,4-difluoro)glutamyl-γ-glutamate to examine the effect of fluori...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2562270/ https://ncbi.nlm.nih.gov/pubmed/18171026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi701607v |
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