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Synthesis of Isopeptide Epoxide Peptidomimetics

Two epoxide-containing peptidomimetics of the isopeptide, glutamyl-γ-glutamate, have been synthesized via a route that should be generally applicable to the synthesis of isopeptide analogs in which an oxirane replaces the scissile peptide bond. Enzymes that catalyze the hydrolysis of peptides and is...

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Autori principali: Majumdar, Debatosh, Alexander, Matthew D., Coward, James K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650424/
https://ncbi.nlm.nih.gov/pubmed/19086784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo801907p
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