A Conserved Acidic Residue in Phenylalanine Hydroxylase Contributes to Cofactor Affinity and Catalysis

[Image: see text] The catalytic domains of aromatic amino acid hydroxylases (AAAHs) contain a non-heme iron coordinated to a 2-His-1-carboxylate facial triad and two water molecules. Asp139 from Chromobacterium violaceum PAH (cPAH) resides within the second coordination sphere and contributes key hy...

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Détails bibliographiques
Publié dans:Biochemistry
Auteurs principaux: Ronau, Judith A., Paul, Lake N., Fuchs, Julian E., Liedl, Klaus R., Abu-Omar, Mahdi M., Das, Chittaranjan
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2014
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4222540/
https://ncbi.nlm.nih.gov/pubmed/25295853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500734h
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