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A Comprehensive Evaluation of Biomarkers Predictive of Response to PI3K Inhibitors and of Resistance Mechanisms in Head and Neck Squamous Cell Carcinoma

The PI3K/AKT/mTOR pathway is frequently activated in head and neck squamous cell carcinoma (HNSCC), but pathway inhibition has variable efficacy. Identification of predictive biomarkers and mechanisms of resistance would allow selection of patients most likely to respond and novel therapeutic combin...

詳細記述

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書誌詳細
出版年:Mol Cancer Ther
主要な著者: Mazumdar, Tuhina, Byers, Lauren A., Shing Ng, Patrick Kwok, Mills, Gordon B., Peng, Shaohua, Diao, Lixia, Fan, You-Hong, Stemke-Hale, Katherine, Heymach, John V., Myers, Jeffrey N., Glisson, Bonnie S., Johnson, Faye M.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4221385/
https://ncbi.nlm.nih.gov/pubmed/25193510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-1090
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