A Comprehensive Evaluation of Biomarkers Predictive of Response to PI3K Inhibitors and of Resistance Mechanisms in Head and Neck Squamous Cell Carcinoma

The PI3K/AKT/mTOR pathway is frequently activated in head and neck squamous cell carcinoma (HNSCC), but pathway inhibition has variable efficacy. Identification of predictive biomarkers and mechanisms of resistance would allow selection of patients most likely to respond and novel therapeutic combin...

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Publicado no:Mol Cancer Ther
Main Authors: Mazumdar, Tuhina, Byers, Lauren A., Shing Ng, Patrick Kwok, Mills, Gordon B., Peng, Shaohua, Diao, Lixia, Fan, You-Hong, Stemke-Hale, Katherine, Heymach, John V., Myers, Jeffrey N., Glisson, Bonnie S., Johnson, Faye M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4221385/
https://ncbi.nlm.nih.gov/pubmed/25193510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-1090
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