Dasatinib induces DNA damage and activates DNA repair pathways leading to senescence in non-small cell lung cancer cell lines with kinase-inactivating BRAF mutations

Improved therapies are greatly needed for non-small cell lung cancer (NSCLC) that does not harbor targetable kinase mutations or translocations. We previously demonstrated that NSCLC cells that harbor kinase-inactivating BRAF mutations ((KI)BRAF) undergo senescence when treated with the multitargete...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Peng, Shaohua, Sen, Banibrata, Mazumdar, Tuhina, Byers, Lauren A., Diao, Lixia, Wang, Jing, Tong, Pan, Giri, Uma, Heymach, John V., Kadara, Humam N., Johnson, Faye M.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808018/
https://ncbi.nlm.nih.gov/pubmed/26623721
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