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Reciprocal regulation of c-Src and STAT3 in non-small cell lung cancer

PURPOSE: STAT3 (signal transducer and activator of transcription-3) is downstream of growth factor and cytokine receptors and regulates key oncogenic pathways in non-small cell lung cancer (NSCLC). Activation of STAT3 by c-Src promotes tumor progression. We hypothesized that c-Src inhibition could a...

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Detalhes bibliográficos
Main Authors: Byers, Lauren Averett, Sen, Banibrata, Saigal, Babita, Diao, Lixia, Wang, Jing, Nanjundan, Meera, Cascone, Tina, Mills, Gordon B., Heymach, John V., Johnson, Faye M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935176/
https://ncbi.nlm.nih.gov/pubmed/19861436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-0767
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