IT-15 DELTA-24-RGDOX: TARGETING CO-STIMULATORY IMMUNE CHECKPOINT PROTEINS WITH ONCOLYTIC ADENOVIRUSES

OX40 ligand (OX40L), the ligand for OX40 on activated CD4+ and CD8+ T cells, has adjuvant properties for establishing effective T-cell immunity against cancer. The hypothesis of this study is that oncolytic viruses expressing OX40L will stimulate tumor-specific T cells by the OX40L-OX40 engagement....

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Autors principals: Jiang, Hong, Lang, Frederick, Fan, Xuejun, Gumin, Joy, Bover, Laura, Clise-Dwyer, Karen, Toniatti, Carlo, Ruisaard, Kathryn, Conrad, Charles, Vence, Luis, Gomez-Manzano, Candelaria, Fueyo, Juan
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
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Abstracts
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218231/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou258.13
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