Localized Treatment with Oncolytic Adenovirus Delta-24-RGDOX Induces Systemic Immunity against Disseminated Subcutaneous and Intracranial Melanomas

PURPOSE: Intratumoral injection of oncolytic adenovirus Delta-24-RGDOX induces efficacious anti-glioma immunity in syngeneic glioma mouse models. We hypothesized that localized treatment with the virus is effective against disseminated melanomas. EXPERIMENTAL DESIGN: We tested the therapeutic effect...

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Publicado en:Clin Cancer Res
Autores principales: Jiang, Hong, Shin, Dong Ho, Nguyen, Teresa T., Fueyo, Juan, Fan, Xuejun, Henry, Verlene, Carrillo, Caroline C., Yi, Yanhua, Alonso, Marta M., Collier, Tiara L., Yuan, Ying, Lang, Frederick F., Gomez-Manzano, Candelaria
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6858961/
https://ncbi.nlm.nih.gov/pubmed/31455679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-0405
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