Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial–mesenchymal transition

Pyruvate kinase M2 (PKM2) is an alternatively spliced variant of the pyruvate kinase gene that is preferentially expressed during embryonic development and in cancer cells. PKM2 alters the final rate-limiting step of glycolysis, resulting in the cancer-specific Warburg effect (also referred to as ae...

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Dades bibliogràfiques
Autors principals: Hamabe, Atsushi, Konno, Masamitsu, Tanuma, Nobuhiro, Shima, Hiroshi, Tsunekuni, Kenta, Kawamoto, Koichi, Nishida, Naohiro, Koseki, Jun, Mimori, Koshi, Gotoh, Noriko, Yamamoto, Hirofumi, Doki, Yuichiro, Mori, Masaki, Ishii, Hideshi
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217454/
https://ncbi.nlm.nih.gov/pubmed/25313085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407717111
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