Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial–mesenchymal transition

Pyruvate kinase M2 (PKM2) is an alternatively spliced variant of the pyruvate kinase gene that is preferentially expressed during embryonic development and in cancer cells. PKM2 alters the final rate-limiting step of glycolysis, resulting in the cancer-specific Warburg effect (also referred to as ae...

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Bibliografski detalji
Glavni autori: Hamabe, Atsushi, Konno, Masamitsu, Tanuma, Nobuhiro, Shima, Hiroshi, Tsunekuni, Kenta, Kawamoto, Koichi, Nishida, Naohiro, Koseki, Jun, Mimori, Koshi, Gotoh, Noriko, Yamamoto, Hirofumi, Doki, Yuichiro, Mori, Masaki, Ishii, Hideshi
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217454/
https://ncbi.nlm.nih.gov/pubmed/25313085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1407717111
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