Combined evaluation of hexokinase 2 and phosphorylated pyruvate dehydrogenase-E1α in invasive front lesions of colorectal tumors predicts cancer metabolism and patient prognosis

Although numerous studies have shown the significance of cancer-specific aerobic glycolysis, how glycolysis contributes to tumor invasion, a critical phenomenon in metastasis, remains unclear. With regard to colorectal cancer (CRC), we studied two critical gate enzymes, hexokinase 2 (HK2), which is...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Hamabe, Atsushi, Yamamoto, Hirofumi, Konno, Masamitsu, Uemura, Mamoru, Nishimura, Junichi, Hata, Taishi, Takemasa, Ichiro, Mizushima, Tsunekazu, Nishida, Naohiro, Kawamoto, Koichi, Koseki, Jun, Doki, Yuichiro, Mori, Masaki, Ishii, Hideshi
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4462394/
https://ncbi.nlm.nih.gov/pubmed/25060325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12487
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