BRAF(V600E) inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells

Although BRAF(V600E) mutation is associated with adverse clinical outcomes in patients with colorectal cancer (CRC), response and resistance mechanisms for therapeutic BRAF(V600E) inhibitors remains poorly understood. In the present study, we demonstrate that selective BRAF(V600E) inhibition activat...

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Pubblicato in:Sci Rep
Autori principali: Sueda, Toshinori, Sakai, Daisuke, Kawamoto, Koichi, Konno, Masamitsu, Nishida, Naohiro, Koseki, Jun, Colvin, Hugh, Takahashi, Hidekazu, Haraguchi, Naotsugu, Nishimura, Junichi, Hata, Taishi, Takemasa, Ichiro, Mizushima, Tsunekazu, Yamamoto, Hirofumi, Satoh, Taroh, Doki, Yuichiro, Mori, Masaki, Ishii, Hideshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707439/
https://ncbi.nlm.nih.gov/pubmed/26750638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18949
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