BRAF(V600E) inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells

Although BRAF(V600E) mutation is associated with adverse clinical outcomes in patients with colorectal cancer (CRC), response and resistance mechanisms for therapeutic BRAF(V600E) inhibitors remains poorly understood. In the present study, we demonstrate that selective BRAF(V600E) inhibition activat...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Sueda, Toshinori, Sakai, Daisuke, Kawamoto, Koichi, Konno, Masamitsu, Nishida, Naohiro, Koseki, Jun, Colvin, Hugh, Takahashi, Hidekazu, Haraguchi, Naotsugu, Nishimura, Junichi, Hata, Taishi, Takemasa, Ichiro, Mizushima, Tsunekazu, Yamamoto, Hirofumi, Satoh, Taroh, Doki, Yuichiro, Mori, Masaki, Ishii, Hideshi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707439/
https://ncbi.nlm.nih.gov/pubmed/26750638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18949
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