BRAF(V600E) inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells

Although BRAF(V600E) mutation is associated with adverse clinical outcomes in patients with colorectal cancer (CRC), response and resistance mechanisms for therapeutic BRAF(V600E) inhibitors remains poorly understood. In the present study, we demonstrate that selective BRAF(V600E) inhibition activat...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sueda, Toshinori, Sakai, Daisuke, Kawamoto, Koichi, Konno, Masamitsu, Nishida, Naohiro, Koseki, Jun, Colvin, Hugh, Takahashi, Hidekazu, Haraguchi, Naotsugu, Nishimura, Junichi, Hata, Taishi, Takemasa, Ichiro, Mizushima, Tsunekazu, Yamamoto, Hirofumi, Satoh, Taroh, Doki, Yuichiro, Mori, Masaki, Ishii, Hideshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707439/
https://ncbi.nlm.nih.gov/pubmed/26750638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18949
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