Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer

Deranged metabolism is a hallmark of cancer, playing a significant role in driving the disease process. One such example is the induction of carcinogenesis by the oncometabolite D-2 hydroxyglutarate (D-2HG), which is produced by the mutated enzyme isocitrate dehydrogenase (IDH) occurring in subsets...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Colvin, Hugh, Nishida, Naohiro, Konno, Masamitsu, Haraguchi, Naotsugu, Takahashi, Hidekazu, Nishimura, Junichi, Hata, Taishi, Kawamoto, Koichi, Asai, Ayumu, Tsunekuni, Kenta, Koseki, Jun, Mizushima, Tsunekazu, Satoh, Taroh, Doki, Yuichiro, Mori, Masaki, Ishii, Hideshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5099755/
https://ncbi.nlm.nih.gov/pubmed/27824159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36289
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