CD44/CD133-Positive Colorectal Cancer Stem Cells are Sensitive to Trifluridine Exposure

Cancer stem cells (CSCs) are involved in metastatic colorectal cancer recurrence, but no effective therapy targeting these cells is currently available. Because trifluridine (FTD)/tipiracil therapy is used for refractory colorectal cancer, we sought to determine whether FTD is effective against CSC-...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Tsunekuni, Kenta, Konno, Masamitsu, Haraguchi, Naotsugu, Koseki, Jun, Asai, Ayumu, Matsuoka, Kazuaki, Kobunai, Takashi, Takechi, Teiji, Doki, Yuichiro, Mori, Masaki, Ishii, Hideshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6795793/
https://ncbi.nlm.nih.gov/pubmed/31619711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50968-6
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