Trifluridine/tipiracil overcomes the resistance of human gastric 5-fluorouracil-refractory cells with high thymidylate synthase expression

von Matsuoka, Kazuaki, Nakagawa, Fumio, Kobunai, Takashi, Takechi, Teiji
Veröffentlicht in Oncotarget (2018)

Synergistic anticancer activity of a novel oral chemotherapeutic agent containing trifluridine and tipiracil in combination with anti-PD-1 blockade in microsatellite stable-type mu...

von Suzuki, Norihiko, Tsukihara, Hiroshi, Nakagawa, Fumio, Kobunai, Takashi, Takechi, Teiji
Veröffentlicht in Am J Cancer Res (2017)

Establishment and Characterization of 6‐[[2‐(Dimethylamino)ethyl]amino]‐3‐hydroxy‐7H‐indeno[2,1‐c]quinolin‐7‐one dihydrochloride (TAS‐103)‐resistant Cell Lines...

von Aoyagi, Yoshimi, Kobunai, Takashi, Utsugi, Teruhiro, Wierzba, Konstanty, Yamada, Yuji
Veröffentlicht in Jpn J Cancer Res (2000)

In vitro Antitumor Activity of TAS‐103, a Novel Quinoline Derivative That Targets Topoisomerases I and II

von Aoyagi, Yoshimi, Kobunai, Takashi, Utsugi, Teruhiro, Oh‐hara, Tomoko, Yamada, Yuji
Veröffentlicht in Jpn J Cancer Res (1999)

MicroRNA profiles involved in trifluridine resistance

von Tsunekuni, Kenta, Konno, Masamitsu, Asai, Ayumu, Koseki, Jun, Kobunai, Takashi, Takechi, Teiji, Doki, Yuichiro, Mori, Masaki, Ishii, Hideshi
Veröffentlicht in Oncotarget (2017)

Combination therapy using oral S-1 and targeted agents against human tumor xenografts in nude mice

von NUKATSUKA, MAMORU, SAITO, HITOSHI, NAKAGAWA, FUMIO, TSUJIMOTO, HIROAKI, SAKAMOTO, KAZUKI, TSUKIOKA, SAYAKA, UCHIDA, JUNJI, KINIWA, MAMORU, KOBUNAI, TAKASHI, TAKECHI, TEIJI
Veröffentlicht 2012

Prognostic impact of KRAS mutant type and MET amplification in metastatic and recurrent gastric cancer patients treated with first-line S-1 plus cisplatin chemotherapy

von Matsusaka, Satoshi, Kobunai, Takashi, Yamamoto, Noriko, Chin, Keisho, Ogura, Mariko, Tanaka, Gotaro, Matsuoka, Kazuaki, Ishikawa, Yuichi, Mizunuma, Nobuyuki, Yamaguchi, Toshiharu
Veröffentlicht in Genes Cancer (2016)

CD44/CD133-Positive Colorectal Cancer Stem Cells are Sensitive to Trifluridine Exposure

von Tsunekuni, Kenta, Konno, Masamitsu, Haraguchi, Naotsugu, Koseki, Jun, Asai, Ayumu, Matsuoka, Kazuaki, Kobunai, Takashi, Takechi, Teiji, Doki, Yuichiro, Mori, Masaki, Ishii, Hideshi
Veröffentlicht in Sci Rep (2019)

Inhibition of PI3K suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil

von Ishida, Kaoru, Ito, Chie, Ohmori, Yukimi, Kume, Kohei, Sato, Kei A., Koizumi, Yuka, Konta, Akari, Iwaya, Takeshi, Nukatsuka, Mamoru, Kobunai, Takashi, Takechi, Teiji, Nishizuka, Satoshi S.
Veröffentlicht in Sci Rep (2017)

Increased Copy Number Variation of mtDNA in an Array-based Digital PCR Assay Predicts Ulcerative Colitis-associated Colorectal Cancer

von TANAKA, TOSHIAKI, KOBUNAI, TAKASHI, YAMAMOTO, YOKO, MURONO, KOJI, OTANI, KENSUKE, YASUDA, KOJI, NISHIKAWA, TAKESHI, KIYOMATSU, TOMOMICHI, KAWAI, KAZUSHIGE, HATA, KEISUKE, NOZAWA, HIROAKI, ISHIHARA, SOICHIRO, WATANABE, TOSHIAKI
Veröffentlicht in In Vivo (2017)

Colitic Cancer Develops Through Mutational Alteration Distinct from that in Sporadic Colorectal Cancer: A Comparative Analysis of Mutational Rates at Each Step

von TANAKA, TOSHIAKI, KOBUNAI, TAKASHI, YAMAMOTO, YOKO, EMOTO, SHIGENOBU, MURONO, KOJI, KANEKO, MANABU, SASAKI, KAZUHITO, OTANI, KENSUKE, NISHIKAWA, TAKESHI, KAWAI, KAZUSHIGE, HATA, KEISUKE, NOZAWA, HIROAKI, WATANABE, TOSHIAKI
Veröffentlicht in Cancer Genomics Proteomics (2017)

Novel 5-fluorouracil-resistant human esophageal squamous cell carcinoma cells with dihydropyrimidine dehydrogenase overexpression

von Kikuchi, Osamu, Ohashi, Shinya, Nakai, Yukie, Nakagawa, Shunsaku, Matsuoka, Kazuaki, Kobunai, Takashi, Takechi, Teiji, Amanuma, Yusuke, Yoshioka, Masahiro, Ida, Tomomi, Yamamoto, Yoshihiro, Okuno, Yasushi, Miyamoto, Shin’ichi, Nakagawa, Hiroshi, Matsubara, Kazuo, Chiba, Tsutomu, Muto, Manabu
Veröffentlicht in Am J Cancer Res (2015)