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In vitro Antitumor Activity of TAS‐103, a Novel Quinoline Derivative That Targets Topoisomerases I and II

TAS‐103 is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II, that stabilizes cleavable complexes of Topo‐DNA at the cellular level. In this study, the in vitro antitumor effects of TAS‐103 were compared with those of other known Topo I and Topo II inhibitors. TAS‐103 inhibi...

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Detalhes bibliográficos
Publicado no:Jpn J Cancer Res
Main Authors: Aoyagi, Yoshimi, Kobunai, Takashi, Utsugi, Teruhiro, Oh‐hara, Tomoko, Yamada, Yuji
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926096/
https://ncbi.nlm.nih.gov/pubmed/10391099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1999.tb00786.x
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