Antitumor Activity of a Novel Quinoline Derivative, TAS‐103, with Inhibitory Effects on Topoisomerases I and II

A novel quinoline derivative, TAS‐103 (6‐[[2‐(dimethyIamino)ethyl]amino]‐3‐hydroxy‐7H‐indeno[2,l‐c]quinolin‐7‐one dihydrochloride), was developed as an anticancer agent targeting topoisomerases (topo) I and II, with marked efficacy in solid tumors. TAS‐103 inhibited topo I and II (IC(50): 2 μM, 6.5...

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Vydáno v:Jpn J Cancer Res
Hlavní autoři: Utsugi, Teruhiro, Aoyagi, Kumio, Asao, Tetsuji, Okazaki, Shinji, Aoyagi, Yoshimi, Sano, Masaki, Wierzba, Konstanty, Yamada, Yuji
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 1997
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921285/
https://ncbi.nlm.nih.gov/pubmed/9414662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1997.tb00320.x
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