Pyruvate kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells

The M2 isoform of pyruvate kinase, the final rate-limiting enzyme of aerobic glycolysis, is expressed during embryonic development. In contrast, the M1 isoform is expressed in differentiated cells due to alternative splicing. Here we investigated murine embryonic stem cells (ESCs) with Pkm1 or Pkm2...

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Detalhes bibliográficos
Publicado no:Regen Ther
Main Authors: Konno, Masamitsu, Ishii, Hideshi, Koseki, Jun, Tanuma, Nobuhiro, Nishida, Naohiro, Kawamoto, Koichi, Nishimura, Tatsunori, Nakata, Asuka, Matsui, Hidetoshi, Noguchi, Kozou, Ozaki, Miyuki, Noguchi, Yuko, Shima, Hiroshi, Gotoh, Noriko, Nagano, Hiroaki, Doki, Yuichiro, Mori, Masaki
Formato: Artigo
Idioma:Inglês
Publicado em: Japanese Society for Regenerative Medicine 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581773/
https://ncbi.nlm.nih.gov/pubmed/31245442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.reth.2015.01.001
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