Pyruvate kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells

The M2 isoform of pyruvate kinase, the final rate-limiting enzyme of aerobic glycolysis, is expressed during embryonic development. In contrast, the M1 isoform is expressed in differentiated cells due to alternative splicing. Here we investigated murine embryonic stem cells (ESCs) with Pkm1 or Pkm2...

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Bibliographic Details
Published in:Regen Ther
Main Authors: Konno, Masamitsu, Ishii, Hideshi, Koseki, Jun, Tanuma, Nobuhiro, Nishida, Naohiro, Kawamoto, Koichi, Nishimura, Tatsunori, Nakata, Asuka, Matsui, Hidetoshi, Noguchi, Kozou, Ozaki, Miyuki, Noguchi, Yuko, Shima, Hiroshi, Gotoh, Noriko, Nagano, Hiroaki, Doki, Yuichiro, Mori, Masaki
Format: Artigo
Language:Inglês
Published: Japanese Society for Regenerative Medicine 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6581773/
https://ncbi.nlm.nih.gov/pubmed/31245442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.reth.2015.01.001
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