Optimization of Critical Hairpin Features Allows miRNA-based Gene Knockdown Upon Single-copy Transduction

Gene knockdown using micro RNA (miRNA)-based vector constructs is likely to become a prominent gene therapy approach. It was the aim of this study to improve the efficiency of gene knockdown through optimizing the structure of miRNA mimics. Knockdown of two target genes was analyzed: CCR5 and green...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Myburgh, Renier, Cherpin, Ophélie, Schlaepfer, Erika, Rehrauer, Hubert, Speck, Roberto F, Krause, Karl-Heinz, Salmon, Patrick
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group 2014
विषय:
Original Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217082/
https://ncbi.nlm.nih.gov/pubmed/25350582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2014.58
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