Lentivector Knockdown of CCR5 in Hematopoietic Stem and Progenitor Cells Confers Functional and Persistent HIV-1 Resistance in Humanized Mice

Gene-engineered CD34(+) hematopoietic stem and progenitor cells (HSPCs) can be used to generate an HIV-1-resistant immune system. However, a certain threshold of transduced HSPCs might be required for transplantation into mice for creating an HIV-resistant immune system. In this study, we combined C...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Myburgh, Renier, Ivic, Sandra, Pepper, Michael S., Gers-Huber, Gustavo, Li, Duo, Audigé, Annette, Rochat, Mary-Aude, Jaquet, Vincent, Regenass, Stephan, Manz, Markus G., Salmon, Patrick, Krause, Karl-Heinz, Speck, Roberto F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Gene Delivery
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4468501/
https://ncbi.nlm.nih.gov/pubmed/25903342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00277-15
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