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Optimizing Synthetic miRNA Minigene Architecture for Efficient miRNA Hairpin Concatenation and Multi-target Gene Knockdown

Synthetic microRNA (miRNA) minigenes (SMIGs) have a major potential for molecular therapy; however, their optimal architecture still needs to be determined. We have previously optimized the stem structure of miRNA hairpins for efficient gene knockdown. Here, we investigate the overall architecture o...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Mol Ther Nucleic Acids
Päätekijät: Rousset, Francis, Salmon, Patrick, Bredl, Simon, Cherpin, Ophélie, Coelho, Marta, Myburgh, Renier, Alessandrini, Marco, Perny, Michael, Roccio, Marta, Speck, Roberto F., Senn, Pascal, Krause, Karl Heinz
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Gene & Cell Therapy 2018
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6350225/
https://ncbi.nlm.nih.gov/pubmed/30665184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.12.004
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