Optimizing Synthetic miRNA Minigene Architecture for Efficient miRNA Hairpin Concatenation and Multi-target Gene Knockdown

Synthetic microRNA (miRNA) minigenes (SMIGs) have a major potential for molecular therapy; however, their optimal architecture still needs to be determined. We have previously optimized the stem structure of miRNA hairpins for efficient gene knockdown. Here, we investigate the overall architecture o...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Mol Ther Nucleic Acids
Κύριοι συγγραφείς: Rousset, Francis, Salmon, Patrick, Bredl, Simon, Cherpin, Ophélie, Coelho, Marta, Myburgh, Renier, Alessandrini, Marco, Perny, Michael, Roccio, Marta, Speck, Roberto F., Senn, Pascal, Krause, Karl Heinz
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society of Gene & Cell Therapy 2018
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6350225/
https://ncbi.nlm.nih.gov/pubmed/30665184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.12.004
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