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Optimizing Synthetic miRNA Minigene Architecture for Efficient miRNA Hairpin Concatenation and Multi-target Gene Knockdown
Synthetic microRNA (miRNA) minigenes (SMIGs) have a major potential for molecular therapy; however, their optimal architecture still needs to be determined. We have previously optimized the stem structure of miRNA hairpins for efficient gene knockdown. Here, we investigate the overall architecture o...
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| Published in: | Mol Ther Nucleic Acids |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society of Gene & Cell Therapy
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6350225/ https://ncbi.nlm.nih.gov/pubmed/30665184 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.12.004 |
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