Optimizing Synthetic miRNA Minigene Architecture for Efficient miRNA Hairpin Concatenation and Multi-target Gene Knockdown

Synthetic microRNA (miRNA) minigenes (SMIGs) have a major potential for molecular therapy; however, their optimal architecture still needs to be determined. We have previously optimized the stem structure of miRNA hairpins for efficient gene knockdown. Here, we investigate the overall architecture o...

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Pubblicato in:Mol Ther Nucleic Acids
Autori principali: Rousset, Francis, Salmon, Patrick, Bredl, Simon, Cherpin, Ophélie, Coelho, Marta, Myburgh, Renier, Alessandrini, Marco, Perny, Michael, Roccio, Marta, Speck, Roberto F., Senn, Pascal, Krause, Karl Heinz
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6350225/
https://ncbi.nlm.nih.gov/pubmed/30665184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.12.004
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