Vpx mediated degradation of SAMHD1 has only a very limited effect on lentiviral transduction rate in ex vivo cultured HSPCs()

Understanding how to achieve efficient transduction of hematopoietic stem and progenitor cells (HSPCs), while preserving their long-term ability to self-reproduce, is key for applying lentiviral-based gene engineering methods. SAMHD1 is an HIV-1 restriction factor in myeloid and resting CD4(+) T cel...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Stem Cell Res
Egile Nagusiak: Li, Duo, Schlaepfer, Erika, Audigé, Annette, Rochat, Mary-Aude, Ivic, Sandra, Knowlton, Caitlin N., Kim, Baek, Keppler, Oliver T., Speck, Roberto F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766840/
https://ncbi.nlm.nih.gov/pubmed/26207584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2015.06.012
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