Evolutionary and Functional Analyses of the Interaction between the Myeloid Restriction Factor SAMHD1 and the Lentiviral Vpx Protein

SAMHD1 has recently been identified as an HIV-1 restriction factor operating in myeloid cells. As a countermeasure, the Vpx accessory protein from HIV-2 and certain lineages of SIV have evolved to antagonize SAMHD1 by inducing its ubiquitin-proteasome-dependent degradation. Here, we show that SAMHD1...

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Main Authors: Laguette, Nadine, Rahm, Nadia, Sobhian, Bijan, Chable-Bessia, Christine, Münch, Jan, Snoeck, Joke, Sauter, Daniel, Switzer, William M., Heneine, Walid, Kirchhoff, Frank, Delsuc, Frédéric, Telenti, Amalio, Benkirane, Monsef
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595996/
https://ncbi.nlm.nih.gov/pubmed/22305291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2012.01.007
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