Evolutionary and Functional Analyses of the Interaction between the Myeloid Restriction Factor SAMHD1 and the Lentiviral Vpx Protein

SAMHD1 has recently been identified as an HIV-1 restriction factor operating in myeloid cells. As a countermeasure, the Vpx accessory protein from HIV-2 and certain lineages of SIV have evolved to antagonize SAMHD1 by inducing its ubiquitin-proteasome-dependent degradation. Here, we show that SAMHD1...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Laguette, Nadine, Rahm, Nadia, Sobhian, Bijan, Chable-Bessia, Christine, Münch, Jan, Snoeck, Joke, Sauter, Daniel, Switzer, William M., Heneine, Walid, Kirchhoff, Frank, Delsuc, Frédéric, Telenti, Amalio, Benkirane, Monsef
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595996/
https://ncbi.nlm.nih.gov/pubmed/22305291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2012.01.007
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados