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Vpx mediated degradation of SAMHD1 has only a very limited effect on lentiviral transduction rate in ex vivo cultured HSPCs()

Understanding how to achieve efficient transduction of hematopoietic stem and progenitor cells (HSPCs), while preserving their long-term ability to self-reproduce, is key for applying lentiviral-based gene engineering methods. SAMHD1 is an HIV-1 restriction factor in myeloid and resting CD4(+) T cel...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Stem Cell Res
Prif Awduron: Li, Duo, Schlaepfer, Erika, Audigé, Annette, Rochat, Mary-Aude, Ivic, Sandra, Knowlton, Caitlin N., Kim, Baek, Keppler, Oliver T., Speck, Roberto F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766840/
https://ncbi.nlm.nih.gov/pubmed/26207584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.scr.2015.06.012
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