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Cholesterol Ester Oxidation by Mycobacterial Cytochrome P450

Mycobacteria share a common cholesterol degradation pathway initiated by oxidation of the alkyl side chain by enzymes of cytochrome P450 (CYP) families 125 and 142. Structural and sequence comparisons of the two enzyme families revealed two insertions into the N-terminal region of the CYP125 family...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Frank, Daniel J., Madrona, Yarrow, Ortiz de Montellano, Paul R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215225/
https://ncbi.nlm.nih.gov/pubmed/25210044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.602771
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