Analysis of Cytochrome P450 CYP119 Ligand-dependent Conformational Dynamics by Two-dimensional NMR and X-ray Crystallography

Defining the conformational states of cytochrome P450 active sites is critical for the design of agents that minimize drug-drug interactions, the development of isoform-specific P450 inhibitors, and the engineering of novel oxidative catalysts. We used two-dimensional (1)H,(15)N HSQC chemical shift...

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Vydáno v:J Biol Chem
Hlavní autoři: Basudhar, Debashree, Madrona, Yarrow, Kandel, Sylvie, Lampe, Jed N., Nishida, Clinton R., de Montellano, Paul R. Ortiz
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4400317/
https://ncbi.nlm.nih.gov/pubmed/25670859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.627935
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