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Two-dimensional NMR and All-atom Molecular Dynamics of Cytochrome P450 CYP119 Reveal Hidden Conformational Substates

Cytochrome P450 enzymes are versatile catalysts involved in a wide variety of biological processes from hormonal regulation and antibiotic synthesis to drug metabolism. A hallmark of their versatility is their promiscuous nature, allowing them to recognize a wide variety of chemically diverse substr...

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Detalhes bibliográficos
Main Authors: Lampe, Jed N., Brandman, Relly, Sivaramakrishnan, Santhosh, de Montellano, Paul R. Ortiz
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843209/
https://ncbi.nlm.nih.gov/pubmed/20097757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.087593
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