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Role of Protein–Protein Interactions in Cytochrome P450-Mediated Drug Metabolism and Toxicity

[Image: see text] Through their unique oxidative chemistry, cytochrome P450 monooxygenases (CYPs) catalyze the elimination of most drugs and toxins from the human body. Protein–protein interactions play a critical role in this process. Historically, the study of CYP–protein interactions has focused...

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Autori principali: Kandel, Sylvie E., Lampe, Jed N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2014
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4164225/
https://ncbi.nlm.nih.gov/pubmed/25133307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx500203s
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