Pro-Regenerative Signaling after Acetaminophen-Induced Acute Liver Injury in Mice Identified Using a Novel Incremental Dose Model

Acetaminophen (APAP) overdose results in acute liver failure and has limited treatment options. Previous studies show that stimulating liver regeneration is critical for survival after APAP overdose, but the mechanisms remain unclear. In this study, we identified major signaling pathways involved in...

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Detalhes bibliográficos
Main Authors: Bhushan, Bharat, Walesky, Chad, Manley, Michael, Gallagher, Tara, Borude, Prachi, Edwards, Genea, Monga, Satdarshan P.S., Apte, Udayan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2014
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215032/
https://ncbi.nlm.nih.gov/pubmed/25193591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.07.019
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