Pro-Regenerative Signaling after Acetaminophen-Induced Acute Liver Injury in Mice Identified Using a Novel Incremental Dose Model

Acetaminophen (APAP) overdose results in acute liver failure and has limited treatment options. Previous studies show that stimulating liver regeneration is critical for survival after APAP overdose, but the mechanisms remain unclear. In this study, we identified major signaling pathways involved in...

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Bibliografiske detaljer
Main Authors: Bhushan, Bharat, Walesky, Chad, Manley, Michael, Gallagher, Tara, Borude, Prachi, Edwards, Genea, Monga, Satdarshan P.S., Apte, Udayan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2014
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4215032/
https://ncbi.nlm.nih.gov/pubmed/25193591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.07.019
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