Endogenous Fructose Production and Fructokinase Activation Mediate Renal Injury in Diabetic Nephropathy

Diabetes is associated with activation of the polyol pathway, in which glucose is converted to sorbitol by aldose reductase. Previous studies focused on the role of sorbitol in mediating diabetic complications. However, in the proximal tubule, sorbitol can be converted to fructose, which is then met...

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Main Authors: Lanaspa, Miguel A., Ishimoto, Takuji, Cicerchi, Christina, Tamura, Yoshifuru, Roncal-Jimenez, Carlos A., Chen, Wei, Tanabe, Katsuyuki, Andres-Hernando, Ana, Orlicky, David J., Finol, Esteban, Inaba, Shinichiro, Li, Nanxing, Rivard, Christopher J., Kosugi, Tomoki, Sanchez-Lozada, Laura G., Petrash, J. Mark, Sautin, Yuri Y., Ejaz, A. Ahsan, Kitagawa, Wataru, Garcia, Gabriela E., Bonthron, David T., Asipu, Aruna, Diggle, Christine P., Rodriguez-Iturbe, Bernardo, Nakagawa, Takahiko, Johnson, Richard J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2014
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4214522/
https://ncbi.nlm.nih.gov/pubmed/24876114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013080901
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