Fructokinase activity mediates dehydration-induced renal injury

The epidemic of chronic kidney disease in Nicaragua (Mesoamerican nephropathy) has been linked with recurrent dehydration. Here we tested whether recurrent dehydration may cause renal injury by activation of the polyol pathway, resulting in the generation of endogenous fructose in the kidney that mi...

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Bibliografiske detaljer
Main Authors: Roncal Jimenez, Carlos A, Ishimoto, Takuji, Lanaspa, Miguel A, Rivard, Christopher J, Nakagawa, Takahiko, Ejaz, A. Ahsan, Cicerchi, Christina, Inaba, Shinichiro, Le, MyPhuong, Miyazaki, Makoto, Glaser, Jason, Correa-Rotter, Ricardo, González, Marvin A, Aragón, Aurora, Wesseling, Catharina, Sánchez-Lozada, Laura G, Johnson, Richard J
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4120672/
https://ncbi.nlm.nih.gov/pubmed/24336030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2013.492
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