Endogenous Fructose Production and Fructokinase Activation Mediate Renal Injury in Diabetic Nephropathy

Diabetes is associated with activation of the polyol pathway, in which glucose is converted to sorbitol by aldose reductase. Previous studies focused on the role of sorbitol in mediating diabetic complications. However, in the proximal tubule, sorbitol can be converted to fructose, which is then met...

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Detalhes bibliográficos
Main Authors: Lanaspa, Miguel A., Ishimoto, Takuji, Cicerchi, Christina, Tamura, Yoshifuru, Roncal-Jimenez, Carlos A., Chen, Wei, Tanabe, Katsuyuki, Andres-Hernando, Ana, Orlicky, David J., Finol, Esteban, Inaba, Shinichiro, Li, Nanxing, Rivard, Christopher J., Kosugi, Tomoki, Sanchez-Lozada, Laura G., Petrash, J. Mark, Sautin, Yuri Y., Ejaz, A. Ahsan, Kitagawa, Wataru, Garcia, Gabriela E., Bonthron, David T., Asipu, Aruna, Diggle, Christine P., Rodriguez-Iturbe, Bernardo, Nakagawa, Takahiko, Johnson, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2014
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4214522/
https://ncbi.nlm.nih.gov/pubmed/24876114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013080901
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