Protective role of fructokinase blockade in the pathogenesis of acute kidney injury in mice

Acute kidney injury is associated with high mortality, especially in intensive care unit patients. The polyol pathway is a metabolic route able to convert glucose into fructose. Here we show the detrimental role of endogenous fructose production by the polyol pathway and its metabolism through fruct...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Andres-Hernando, Ana, Li, Nanxing, Cicerchi, Christina, Inaba, Shinichiro, Chen, Wei, Roncal-Jimenez, Carlos, Le, Myphuong T., Wempe, Michael F., Milagres, Tamara, Ishimoto, Takuji, Fini, Mehdi, Nakagawa, Takahiko, Johnson, Richard J., Lanaspa, Miguel A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316807/
https://ncbi.nlm.nih.gov/pubmed/28194018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14181
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