Investigating the role of a backbone to substrate hydrogen bond in OMP decarboxylase using a site-specific amide to ester substitution

Hydrogen bonds between backbone amide groups of enzymes and their substrates are often observed, but their importance in substrate binding and/or catalysis is not easy to investigate experimentally. We describe the generation and kinetic characterization of a backbone amide to ester substitution in...

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Detalhes bibliográficos
Main Authors: Desai, Bijoy J., Goto, Yuki, Cembran, Alessandro, Fedorov, Alexander A., Almo, Steven C., Gao, Jiali, Suga, Hiroaki, Gerlt, John A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210302/
https://ncbi.nlm.nih.gov/pubmed/25275007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411772111
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