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Computational, Structural and Kinetic Evidence that Vibrio vulnificus FrsA is not a Cofactor-Independent Pyruvate Decarboxylase
The fermentation-respiration switch (FrsA) protein in Vibrio vulnificus was recently reported to catalyze the cofactor-independent decarboxylation of pyruvate. We now report QM/MM calculations that examine the energetics of C-C bond cleavage for a pyruvate molecule bound within the putative active s...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3788570/ https://ncbi.nlm.nih.gov/pubmed/23452154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400093y |
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