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Mechanism of the Orotidine 5’-Monophosphate Decarboxylase-Catalyzed Reaction: Importance of Residues in the Orotate Binding Site
The reaction catalyzed by orotidine 5’-monophosphate decarboxylase (OMPDC) is accompanied by exceptional values for the rate enhancement [k(cat)/k(non) = 7.1 × 10(16)] and catalytic proficiency [(k(cat)/K(M))/k(non) = 4.8 × 10(22) M(−1)]. Although a stabilized vinyl carbanion/carbene intermediate is...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3199138/ https://ncbi.nlm.nih.gov/pubmed/21870810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2012355 |
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