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Amide-to-E-Olefin versus Amide-to-Ester Backbone H-Bond Perturbations: Evaluating the O-O Repulsion for Extracting H-Bond Energies

Both amide-to-ester and amide-to-E-olefin backbone amide mutation methods were employed to perturb the same H-bond (formed by the NH of F23 and the CO of R14) in the pin WW domain. Comparison of the thermodynamic folding energies of the ester mutant and the E-olefin mutant, accounting for the transf...

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Autori principali: Fu, Yanwen, Gao, Jianmin, Bieschke, Jan, Dendle, Maria A., Kelly, Jeffery W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2532496/
https://ncbi.nlm.nih.gov/pubmed/17165703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja065303t
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