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Amide-to-E-Olefin versus Amide-to-Ester Backbone H-Bond Perturbations: Evaluating the O-O Repulsion for Extracting H-Bond Energies
Both amide-to-ester and amide-to-E-olefin backbone amide mutation methods were employed to perturb the same H-bond (formed by the NH of F23 and the CO of R14) in the pin WW domain. Comparison of the thermodynamic folding energies of the ester mutant and the E-olefin mutant, accounting for the transf...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2532496/ https://ncbi.nlm.nih.gov/pubmed/17165703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja065303t |
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