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MMS Exposure Promotes Increased MtDNA Mutagenesis in the Presence of Replication-Defective Disease-Associated DNA Polymerase γ Variants

Mitochondrial DNA (mtDNA) encodes proteins essential for ATP production. Mutant variants of the mtDNA polymerase cause mutagenesis that contributes to aging, genetic diseases, and sensitivity to environmental agents. We interrogated mtDNA replication in Saccharomyces cerevisiae strains with disease-...

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書誌詳細
主要な著者: Stumpf, Jeffrey D., Copeland, William C.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207668/
https://ncbi.nlm.nih.gov/pubmed/25340760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004748
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