MMS Exposure Promotes Increased MtDNA Mutagenesis in the Presence of Replication-Defective Disease-Associated DNA Polymerase γ Variants

Mitochondrial DNA (mtDNA) encodes proteins essential for ATP production. Mutant variants of the mtDNA polymerase cause mutagenesis that contributes to aging, genetic diseases, and sensitivity to environmental agents. We interrogated mtDNA replication in Saccharomyces cerevisiae strains with disease-...

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Bibliographic Details
Main Authors: Stumpf, Jeffrey D., Copeland, William C.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207668/
https://ncbi.nlm.nih.gov/pubmed/25340760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004748
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