A thermodynamic perspective on the dock-lock growth mechanism of amyloid fibrils

The mechanism of addition of a soluble unstructured monomer to a preformed ordered amyloid fibril is a complex process. Based on the kinetics of monomer disassociation of Aβ(1 — 40) from the amyloid fibril, it has been suggested that deposition is a multi-step process involving a rapid reversible as...

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Bibliografiske detaljer
Main Authors: O’Brien, Edward P., Okamoto, Yuko, Straub, John. E., Brooks, Bernard R., Thirumalai, D.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4204656/
https://ncbi.nlm.nih.gov/pubmed/19813700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp9050098
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