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Monomer adds to preformed structured oligomers of Aβ-peptides by a two-stage dock–lock mechanism
Nonfibrillar soluble oligomers, which are intermediates in the transition from monomers to amyloid fibrils, may be the toxic species in Alzheimer's disease. To monitor the early events that direct assembly of amyloidogenic peptides we probe the dynamics of formation of (Aβ(16–22))(n) by adding...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1766316/ https://ncbi.nlm.nih.gov/pubmed/17190811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607440104 |
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